Welcome to our site ...

Links to our lab & research are up on top.

Our three Most Recent Publications - and interesting "behind the scenes" stories

1) Sheftic, S.R., Croke, R.L., LaRochelle, J.R., & Alexandrescu, A.T (2009) “Electrostatic Contributions to the Stabilities of Native Proteins and Amyloid Complexes". Methods Enzymology 466: 233-258.

A review on electrostatic contributions to protein stability. The last two sections have a lot of new stuff on amyloidogenic proteins. Out first paper for which the authors recieved a small honorarium instead of having to pay page charges. Yay Methods in Enzymology!

2) Guardino, K.M., Sheftic, S.R., Slattery, R.E., & Alexandrescu, A. (2009) “Relative stabilities of conserved and non-conserved structures in the OB-fold superfamily”. Int. J. Mol. Sci. 10, 2412-2430.

Like all of our best papers, this one was very hard to publish. Judge for yourselves, we're proud of it!

.3) Patil, S.M., Xu, S., Sheftic, S. & Alexandrescu, A. (2009) “Dynamic alpha-helix structure of micelle-bound human amylin”. J. Biol. Chem. 284, 11982-11991.

This whole structure was done with 1 mg of sample and a total cost of ~ $3,000. Of that, $800 was journal page charges. Take that Structural Genomics Initiatives!!!