Amyloids

We are examining the structures of fibrils, intermediates in fibril formation, and the role of cofactors in fibrils.

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Protein Folding

We are interested in the structural characterization of equilibrium folding intermediates, particularly from a family of structurally related proteins that share the same OB-fold. Our long term goal is to use information from experimental protein folding studies to develop improved structure modeling methods.

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Agrin

We are using structural & biophysical techniques to understand the role of this large proteoglycan in the development and maintenance of nerve-muscle synapses.

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